How Does Fish Genetic Testing Work: Unraveling The Science

How does the FISH test work? The FISH (Fluorescence In Situ Hybridization) test is a diagnostic technique used to identify specific genetic abnormalities in cancer cells. To perform a FISH test, a pathologist requires a sample of either your cancerous tissue, obtained through a biopsy or surgery, or a blood sample. In the laboratory, the pathologist employs a specialized process involving the attachment of fluorescent dye to the genetic material of interest within the cells. Subsequently, they use ultraviolet light to examine and quantify any gene changes or abnormalities present in the sample. This method allows for the precise identification and analysis of genetic alterations within cancer cells, providing crucial insights into the nature of the disease and guiding treatment decisions.

Fluorescence in situ hybridization (FISH) is a vital genetic testing technique that enables researchers to visually examine and map the genetic material within an individual’s cells, including the precise location of specific genes or gene segments. By doing so, FISH aids in comprehending a wide range of chromosomal abnormalities and other genetic mutations. For instance, it can help identify missing or extra copies of chromosomes, translocations where genetic material is exchanged between chromosomes, and pinpoint the location of specific genes in relation to their chromosomes. This technique plays a crucial role in both clinical diagnostics and research, allowing scientists to gain valuable insights into genetic variations and their implications for health and disease. [Last updated: August 16, 2020]